Cytokine gene polymorphisms influence gastric disease progression, a 12 year follow-up study
Cytokine gene polymorphisms influence gastric disease progression, a 12 year follow-up study
Robertino Mera, Zabaleta J, Camargo M, Piazuelo M, Bravo L and Correa P
Published in American Journal of Epidemiology, 2009, 169 (Suppl), S6
Abstract: Recent studies have linked cytokine gene polymorphisms to gastric cancer. The current study evaluated the association of interleukin (IL)10 gene polymorphisms in the progression of gastric lesions in subjects from a high-risk area for gastric cancer in Colombia. We prospectively studied 426 subjects with chronic gastritis. Three common polymorphisms in the IL10 gene were genotyped by TaqMan allelic discrimination assays. Gastric biopsies at baseline and 12 years were evaluated for the presence of lesions in the precancerous cascade: multifocal atrophic gastritis – intestinal metaplasia – dysplasia. Carriers of the ATA haplotype of IL10 (rs1800896/rs1800871/rs1800872) were 1.62 (95% CI: 1.14-2.29) times more likely to progress to more severe lesions than the ACC haplotype. These results were independent of H. pylori status; those positive were 1.78 (95% CI: 1.18, 2.69) times more likely to progress independent of haplotype status. There was no interaction between H. pylori status and the IL10 haplotypes. Anti-helicobacter treatment or supplementation with ascorbic acid and beta-carotene were not significantly related to progression after taking into account H. pylori status. Cytokine gene polymorphisms influence the long-term progression of precancerous lesions independent of H. pylori infection. Genetic variations in the IL10 promoter may influence mucosal cytokine expression determining the clinical course of gastric inflammation. These findings contribute to the understanding of the complex interplay between host and bacterial factors involved in the development of gastric pathology.
