Recruitment models in clinical trials
March 30th, 2009
Anisimov VV (2009). Recruitment models in clinical trials. Pharmaceutical Outsourcing, March/April 2009,1–10.
Categories: All, Research Statistics Unit
Publications & White Papers
Archive for March, 2009
An update on discordance
March 26th, 2009
Ohad Amit & Frank Mannino
Categories: All, Research Statistics Unit
An update on discordance
March 26th, 2009
Ohad Amit & Frank Mannino
Categories: All, Research Statistics Unit
Recruitment Modeling and Predicting in Clinical Trials
March 15th, 2009
Anisimov VV (2009). Recruitment modeling and predicting in clinical trials, Pharmaceutical Outsourcing 10(1): 44–48.
Categories: All, Publications, Research Statistics Unit
Penalized designs of multi-response experiments
March 15th, 2009
Penalized designs of multi-response experiments
Valerii Fedorov and Yuehui Wu
Categories: All, Research Statistics Unit
An adaptive optimal design for the Emax model and its application in clinical trials
March 15th, 2009
Categories: All, Research Statistics Unit
An adaptive optimal design for the Emax model and its application in clinical trials
March 2nd, 2009
An adaptive optimal design for the Emax model and its application in clinical trials
Sergei Leonov and Sam Miller
Abstract: A project team working on a compound to treat Alzheimer’s disease is carrying out a first-time-in-human dose-escalation study in patients. The team wished to maximize the efficiency of the study by using doses targeted at maximizing information about the dose-response relationship within certain safety constraints. We have developed an adaptive optimal design tool to recommend doses when the response follows an Emax model, with functionality for pretrial simulation and in-stream analysis. We present the results of a simulation to investigate the operating characteristics of the applied algorithm.
Categories: All, Research Statistics Unit
